All in one solution

In this article we cover:

  • The three main ingredients in Skin+Beyond
  • How it protects dermal fibroblasts, the collagen and elastin producing cells from UV damage by 47%
  • The multiple potential health applications including increased collagen synthesis and protection, joint health and heart health

Skin+Beyond is a premium, vegan friendly, chemical free, “All in one skin solution” containing a synergistic, proprietary blend of patented Pomella® pomegranate extract, glycine (an amino acid) and both forms of vitamin B3, niacin and niacinamide, that offers not only skin enhancing benefits, but multiple potential health applications including increased collagen synthesis and protection, joint health, bone health, heart health, sports performance and recovery and much more making Skin+Beyond a truly hybrid product.

A paradigm shift in anti-ageing

Pomella® patented pomegranate extract (POMx)

  • Contains potent antioxidants, namely punicalagins that are not only unique to pomegranate, but possess powerful bioactive free radical scavenging properties, with Pomella® standardised to 30% punicalagins. Further punicalagins exhibit anti-inflammatory activity and protective effects on DNA and cellular signalling.
  • Protects the mitochondrial DNA of dermal fibroblasts from UV induced damage; POMx was shown to reduce the damage inflicted by free radicals on mitochondrial DNA in skin fibroblasts by 47%, proving almost as efficient as the 56% reduction provided by MitoQ, an artificially engineered antioxidant used to prevent oxidative damage to cells. MitoQ is the best COQ10 on the market, but costs £60 per month, plus POMx has many other therapeutic properties.(1)
  • Induces mitophagy, a process that removes damaged mitochondria (the energy batteries) from the cells. All ageing processes including skin results from impaired cellular energy output; this process is unique to POMx and niacinamide (see below).
  • Prevents and slows glycation, a process where sugar in the form of circulating glucose reacts with proteins, in turn forming advanced glycation end products or AGEs that damage the collagen matrix in skin as well as other areas such as joints; POMx reduces glycation significantly.(2)
  • Pomegranate extract (PE) and its polyphenols have been shown to prevent methylglyoxal (MGO) induced DNA damage of keratin producing cells (keratinocytes) (3)
  • Boosts collagen production in the extracellular matrix (4)
  • Boosts hyaluronic acid levels in the extracellular matrix (5)
  • Reduces hyperpigmentation by reducing melanin synthesis (6)
  • Pomegranate extract (POMx) produces urolithin A in the gut from ellagic acid, a phenol antioxidant found in pomegranate. This amazing finding has only come to light recently and it represents a paradigm shift in bodily ageing. This study showed in relation to skin urolithin A increased type 1 collagen expression and reduced MMP-1 expression. (7)

MMP-1 is largely responsible for collagen degradation along with glycation. Further the study compared retinol with urolithin A and postulated that they both show the aforementioned attributes, but went on to say that urolithin A also boosts Nrf2 expression or in other words boosts the body’s own antioxidant system e.g. glutathione.

This new exciting molecule can be purchased, but it’s synthetically derived in a lab and it costs £80 per month.

NB While vitamin C has become a popular skin enhancing ingredient, the simple reason we don’t add it is that pomegranate extract does everything that vitamin C does and much more, and 500mg of vitamin C is considered the minimum for collagen synthesis.

Glycine can boost collagen production by 200%

Glycine

Boosts collagen production; between 20 and 30, collagen loss starts to outstrip collagen production, leading to structural changes in the connective tissues e.g. skin, joints. Glycine can boost collagen production by 200%.(8)

NB Apart from being expensive, collagen supplements do not translate into collagen absorbed, and you can read about this at the blog, “Collagen supplements – unmasking the truth”.

There is also further evidence to support this (9) that says;

“Collagen hydrolysate has 33% glycine residues (25% of its mass), so 10g of hydrolysate (the daily dose used) means 2.5g of glycine, which is insufficient for the metabolic needs. It may produce a slight improvement, but better results could be achieved with a daily dose of 10g of glycine which we are proposing here. On the other hand, gelatine or collagen hydrolysate are not advantageous as proline or lysine sources because their hydroxylated forms, which means about 30 to 50% of these amino acid residues (Barnes et al.1974), are useless for reutilization. Thus, although results with collagen hydrolysate may be moderate, they are an indication of the glycine needed to propitiate cartilage regeneration.

Therefore, increasing glycine in the diet could be a possible way of contributing to fight and prevention of osteoarthritis to improve cartilage regeneration by means of enhancing collagen synthesis. It may be that the deficiencies mentioned above are not the only cause, but it is certainly a feasible place to start. To this end our results suggest a viable strategy through increasing the amounts of these amino acids (glycine especially) in the diet. As these deficiencies will obviously affect other connective or mechanical tissues, such as bones, tendons, ligaments and skin, we would like to remark that this conclusion might also well be applied in the treatment of these damaged tissues in conditions such as osteoporosis.”

  • Prevents or reduces glycation in turn protecting collagen from degradation and loss.(10)
  • Boosts human growth hormone a.k.a “The youth hormone” or “The anti-ageing hormone” in turn boosting collagen and elastin synthesis and creatine production, in turn boosting muscle synthesis.(11)

Niacinamide boasts all round attributes in skin health

Vitamin B3 (Niacin and niacinamide)

A 2018 study that involved collaboration between anti-ageing expert, Professor Birch-Machin at Newcastle University and OLAY, confirmed many of niacinamide’s anti-ageing attributes.

Niacinamide boosts cellular energy production in all parts of the skin with improving NAD+ (a coenzyme) production that decreases with age, with a loss of 50% every 20 years.

NB The pomegranate derived gut metabolite urolithin A actually boosts NAD+ and SIRT 1, the longevity enzyme.(12)

Niacinamide boasts all round attributes in skin health due to multiple mechanisms of action;

  • Induces mitophagy, a process that removes damaged mitochondria (the energy batteries) from the cells. All ageing processes including skin results from impaired cellular energy output; this process is unique to POMx and niacinamide (13)
  • Reducing redness and blotchiness – Niacinamide dampens inflammation, helping to alleviate eczema, acne and other inflammatory skin problems
  • Reduces pore appearance – Helping to preserve smoothness, as well as reducing pore size over time
  • Oil regulation – Niacinamide also modulates the amount of oil produced by the sebaceous glands, preventing hyperactivity in oil production
  • Protection against UV rays – As well as protect skin cells from UV induced damage, niacinamide helps to rebuild healthy cells
    Improves hyperpigmentation – Niacinamide has shown any study to be useful for lightening dark sports; benefits were observed between 4 and 8 weeks but not beyond 8 weeks and it may be the result of increased collagen production
  • Reduces fine lines and wrinkles – The same study as above found that niacinamide was useful at reducing some signs of UV induced ageing including fine lines and wrinkles
  • Protects against free radicals – Niacinamide protects against free radicals and oxidative stress caused by environmental stressors e.g. sunlight, pollution and toxins
  • Improves acne – Niacinamide can be helpful for severe cases of acne, especially when it’s inflammatory driven evidenced by papules and pustules. It’s possible that over time you will notice less lesions and a healthier skin texture
  • Niacinamide boosts ceramides and other lipids that comprise the outer skin surface in the epidermis (stratum corneum), in turn improving the skin barrier integrity.(14)

You can read about the above benefits at the Healthline website link.(15)